Home / Nootropic Reviews / Prevagen (Apoaequorin) – Does it Improve Memory?

Prevagen (Apoaequorin) – Does it Improve Memory?

PrevagenPrevagen is a nootropic supplement manufactured in the USA by Quincy Bioscience. Two capsule strengths are available (regular + extra strength) and there is also a chewable option for people who have difficulty swallowing pills.

Only one dose is required each day and, according to the marketing material, the most common reported benefits are:

  • Overall improved mental clarity
  • Greater ability to focus
  • Better concentration
  • Clearer thinking

Prevagen in Summary

Ummm, glowing jellyfish!?!?

Maybe it works, for some people, I’m not sure. I will most certainly be the first to write a sci-fi story about it if it becomes a popular and proven thing.

In the meantime, call me backward, but I might stick with the pills that contain things I understand the logic behind.

There’s a post you can have a quick look at, which summarizes all the best nootropic supplements I have tested and reviewed.

Click here to read the summary of the best nootropics

Why Prevagen?

As the human body ages many changes occur. The hair begins to thin or grey, the skin wrinkles, and the mind begins to lose its edge. Failing cognitive function can be indicated in many ways, including:

  • Becoming forgetful
  • Finding it hard to concentrate
  • Fuzzy thinking
  • Mental fatigue

People often begin to notice such changes when they are in their 40s, but problems can start to manifest earlier or later in life. Quincy Bioscience claim supplementation with Prevagen can improve the memory and provide a sharper mind within 90 days.

Ingredients in Prevagen

PrevagenPrevagen contains only one active ingredient. It’s called apoaequorin. The regular and chewable options provide a dose of 10mg. The extra strength version provides twice the amount.

Apoaequorin is a protein that is naturally occurring in glowing jellyfish. When it binds with calcium ions it causes the illumination that provides the jellyfish with their name.

Quincy Bioscience cite a number of studies that appear to suggest apoaequorin may be very similar to a calcium-binding protein found in the human brain, but some of the studies appear to have been conducted in-house or financed by the company, while others were carried out on dogs.

The studies suggest supplementation with apoaequorin may improve calcium homeostasis. Endogenous calcium is known to be important for suppressing cytosolic calcium levels.

A low level of cytosolic calcium is highly desirable because if the level rises it diminishes the performance of important neurons. Unfortunately, as the body grows older the levels tend to rise, resulting in a poor memory and other symptoms of mental decline. If Prevagen can rectify the situation, in theory, the benefits should be good.

However, some of the study data indicates supplementation with apoaequorin may offer the most benefit to users who are already suffering from mild to moderate impairments to their mental function. The data further suggests apoaequorin might offer little or no improvement if the user suffers from moderate to severe impairments to mental function.

Customer Feedback

Customer feedback is mixed.

A few average reviews read:

“I’ve been struggling with these pills for 9 weeks and still have difficulty remembering to take them. That should tell you everything you need to know.”

“I find it easier to concentrate on my work since I began taking Prevagen and can’t remember the last time I lost my keys (pun intended), so I guess these are pretty good brain pills.”

“Don’t be deceived by all the lies. Prevagen does not work. I took it every day for three months and none of the brain fog lifted. My memory is still like a sieve, I often feel confused, and can’t for the life of me remember what convinced me to buy it.”

Side Effects & Health Issues

Nootropic brain healthQuincy Bioscience states the formulation is “very safe and extremely well tolerated” and further claim it offers no harmful side effects. However, a warning letter issued by the FDA, in 2012, indicates otherwise.

The FDA raises many issues about the product, including its potential for side effects. According to the FDA, Quincy Bioscience failed to disclose information about serious side effects (seizures, strokes, heart arrhythmias, and worsening of multiple sclerosis) when they were questioned during an FDA inspection.

FDA inspectors found over 1000 complaints about the product, but Quincy Bioscience had only disclosed information about two of them.


Prevagen is sold with a 30-day money back guarantee.

Purchasing Options & Considerations

A one month supply of Prevagen capsules or chewables costs $59.95 plus shipping when purchased from the manufacturer’s online store. The extra strength capsules cost $10 more.

A number of attractive bulk buy incentives are available and Quincy Bioscience also operates an automated billing and shipping program. Customers who opt for this option can save around $15 per month, but the company does not ship to customers outside the USA.

However, customers based in the UK can purchase 30 Prevagen capsules or chewables from the iHerb website for just £26.02, or choose to pay £39.04 for the extra strength capsules.

Recommendations for Best Results

Mind Lab ProThis may be a churlish thing to say, but potentially unsafe glowing jellyfish protein sounds like something the bad guy might use as a weapon in one of (the late and great) Michael Crichton’s novels. (Actually, I’m pretty sure it was. Don’t quote me on this but I seem to recall State of Fear having something similar).

Anyway, the point is there are many other cognitive-sharpening products available to you without having to venture into the Outer Limits to obtain one.

And just to be super helpful, I’ve collated a brief description of them in a summary post. Read that, and from there you can read the full reviews and even go shopping for them if any take your fancy.

Click here for more info on the best nootropic products

About Ross

Ross is a writer for several online health and fitness magazines. He has designed the formulae for nootropic and ergogenic supplements, and is always on the look out for the next big breakthrough in sports supplement science. An Ironman triathlete and distance runner, Ross loves the endurance game, but he's happy powercleaning a sandbag in the park. Feel free to ask him a question in the comments section.

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