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L-Tyrosine and N-Acetyl-l-Tyrosine (NALT)

N-Acetyl-l-Tyrosine (NALT) is a modified form of L-Tyrosine, which is itself an amino acid that has bioactive benefits in the brain. The NALT version is simply a more soluble compound of the original and so for the purposes of discussion, any information regarding L-Tyrosine can be assumed to be the same for NALT (aside from speed of absorption of course).

n acetyl l tyrosine

L- Tyrosine is known for its anti-stress qualities, especially when taken within the 30 minute window before the mental or physical stressor begins. In practical terms, this may mean taking it just before starting work or going to the gym. Its versatility in this regard is the reason it has been securing a place in many supplements, both nootropic and pre-workout by design.

It improves cognition during periods of stress, essentially helping the user think clearly throughout the fog of anxiety.

How Does N-Acetyl-l-Tyrosine Work?

active brainL-Tyrosine is a precursor to the syntheses of catecholamine, which is the pathway through which most of its effects are exerted. It increases norepinephrine (noradrenaline) in the hippocampus part of the brain and prevents the reduction of the same neurotransmitter during times of stress.

This has the knock-on effect of increasing memory function while the user is experiencing stress and anxiety. The stressor in this case can be physical or mental/emotional. So, L-Tyrosine can improve memory from baseline and reduce the negative effect on it when external stress is applied.

Perhaps one of the most important stressors in an everyday scenario is tiredness. L-Tyrosine can prevent cognitive decline when the user is tired and indeed extend the period of wakefulness itself. Technically, it could be labelled a ‘stimulant’ though it presents none of the negative side effects often associated with stimulants. It simply increases the period of the day in which the user feels alert and attentive.

meeting L-Tyrosine can reduce some of the uncontrollable responses the body has under acute stress. This marries well with other nootropics that may be found in the same supplement, i.e. those that manage the symptoms of chronic or long term stress (burn out, chronic fatigue, depression, over-eating etc.) and so it will often be found alongside Adaptogens like Rhodiola rosea.

There is evidence from human trials that it can mitigate cold and high altitude stress effects such as headaches, fatigue, distress, drowsiness, sore muscles and of course stress. This has interesting implications for the treatment of those symptoms regardless of cold and high altitude being the cause.

The compound also increases attention and has shown promise in studies involving subjects with ADHD. Not only that but catecholamines, which L-Tyrosine is a precursor for, can reduce the effects of dementia/neurological decline.

Are There Other Benefits?

In addition to the powerful cognitive benefits, there are further positive effects of L-Tyrosine:

  • Increased Physical Workout Performance (by decreasing mental fatigue)
  • Slight reduction in Blood Pressure

Where Does N-Acetyl-l-Tyrosine Come From?

L-Tyrosine is a natural amino acid synthesized by the body. The supplemental form, including NALT (as a more bioavailable compound) can be produced.


 brain pushing L-Tyrosine and its more bioavailable version N-Acetyl-l-Tyrosine are valuable nootropic ingredients which reduce acute stress and can improve the user’s performance while under such conditions. This goes well with Adaptogens, which alleviate chronic stress.

The main benefits of prolonged attention span (period of wakefulness) and the ability to think more clearly during times when the confusion of stress might otherwise hinder thought processes are the most valuable.

Think of speaking in front of people, or starting a new job or new task, or a meeting with the boss. Indeed any situation where your mind might inexplicably empty just as you need it to be on the ball. L-Tyrosine can help.

As part of a complete nootropic formula, NALT or L-Tyrosine is a solid performer, and one anti-stress inclusion that’s good to have on your side!


About Ross

Ross is a writer for several online health and fitness magazines. He has designed the formulae for nootropic and ergogenic supplements, and is always on the look out for the next big breakthrough in sports supplement science. An Ironman triathlete and distance runner, Ross loves the endurance game, but he's happy powercleaning a sandbag in the park. Feel free to ask him a question in the comments section.

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