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Huperzine A – Neurotransmitter Booster

hup a structureHuperzine A is a nootropic compound sourced from the Huperziaceae family of herbs. It is often found in brain health supplements and pre-workouts because of its ability to increase neurotransmitter levels, specifically acetylcholine.

Acetylcholine helps us learn. It is in fact the principal neurotransmitter for that purpose. Not only that but it’s also heavily involved in the force of muscle contraction. So, for different reasons that are closely tied, both strength athletes and academics benefit from optimal levels of acetylcholine.

Huperzine A is safe to use and presents no side effects in the average person.

This excellent compound is even being researched for its ability to fight Alzheimer’s disease.

How Does Huperzine-A Work?

brain bulbHup-A, as it is also called, increases levels of the neurotransmitter acetylcholine in the brain. It does this by inhibiting an enzyme called acetylcholinesterase. This enzyme breaks down acetylcholine, so by stopping it to an extent the levels of acetylcholine are allowed to increase.

The compound Huperzine A is water soluble, therefore easily ingestible from oral supplementation. Its initial spike is fast but it also sticks around for a long time, making it both efficient and durable; everything you want from a nootropic ingredient.

Are There Other Benefits

As well as the obvious inhibition of the enzyme acetylcholinesterase, Huperzine-A is a neuro-protective antioxidant.

Where Does Huperzine-A Come From?

There are two general forms of Hup-A, natural and synthetic. The natural type comes from the Huperziaceae family of herbs, from which it is extracted. The synthetic type is bioequivalent to the natural one so it seems either can be used for the quality supplements.

Other plant family sources are Lycopodiaceae and Selaginella. Toothed Clubmoss is a common term used for the Lycopodium/Huperzeria plants from which Huperzine-A.


Nootropic brain healthHup-A is a safe and powerful inhibitor of the enzyme acetylcholinesterase, which in turn results in increased levels of the neurotransmitter acetylcholine. More of that means improved cognitive function.

The compound also protects the brain and rids it of toxins that may cause its physical decline before it otherwise has to be.

It addition to any nootropic supplement is a valuable one, and it will be synergistic with any direct acetylcholine booster.

About Ross

Ross is a writer for several online health and fitness magazines. He has designed the formulae for nootropic and ergogenic supplements, and is always on the look out for the next big breakthrough in sports supplement science. An Ironman triathlete and distance runner, Ross loves the endurance game, but he's happy powercleaning a sandbag in the park. Feel free to ask him a question in the comments section.

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